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Sep 27, 2022 · Abstract. Peptide drugs represent 5% of the global pharmaceutical market, but growing twice as fast as the rest of the drug market. The development of peptide therapeutics is challenging due to their low stability, short half-life, and poor oral bioavailability. However, peptides typically have exquisite potency, selectivity, and low toxicity ...

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Apr 1, 2021 · The use of an albumin binder has been shown to improve tumor uptake of prostate-specific membrane antigen (PSMA)–targeting radiotherapeutic agents. The aim of this study was to develop improved radiotherapeutic agents that combine an optimized affinity-modifying group and optimized albumin binders to maximize the tumor-to-kidney absorbed dose ratio. Methods: 68Ga-labeled DOTA-conjugated ...

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